In August, Hanlon was named to run Home Depot’s Northern Division, which covers some 800 stores in the Midwest and Northeast, with estimated revenue of $27 billion. Hanlon started in 1985 as a cashier, intending to help pay for her training as a physical therapist. She never finished—good news for the company and the 110,000 associates she now manages.

For more on newcomers and returns to the list, read “Who’s on? Who’s off? Fortune’s list of the Most Powerful Women has plenty of changes.”