The British physicist-turned-CFO oversees the finances of the U.S.’s largest bank by assets, with $2.4 trillion. She’s also one of three women on JPMorgan Chase’s operating committee (another is No. 30, Mary Erdoes). Lake is considered a rising star, frequently leading earnings calls and interacting with investors more than most Wall Street finance chiefs. That has led to speculation that she could one day succeed CEO Jamie Dimon. In 2015 the bank reported $93.5 billion in revenue; its net income was up 12%, to $24.4 billion.