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Global 500

Courtesy of Express Scripts Holding


Express Scripts Holding



Over the past decade, Express Scripts has become the largest pharmacy benefit manager in the U.S. as the industry has consolidated. The company processes more than 1.5 billion claims every year. The question now is if it can compete using its unique stand-alone business model with rivals like CVS Health that pursue a multi-pronged approach. Express Scripts has benefited from the wave of newly insured patients as a result of the Affordable Care Act and has significantly expanded its profit margins over the past six years. The company’s simmering contract dispute with insurance giant Anthem, its largest customer and 18% of its revenue, was an undercurrent to 2016; the companies severed ties in April 2017, sending Express Scripts’ stock plummeting. The move leaves the company to find a way forward as it still covers 65 million people and processes about 1 billion prescriptions a year.

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Timothy C. Wentworth


Health Care


Health Care: Pharmacy and Other Services

HQ Location

St. Louis, MO

Years on Global 500 List




Key Financials (Last Fiscal Year)
($ Millions)% change
Revenues ($M)$100,288-1.4%
Profits ($M)$3,404.437.5%
Assets ($M)$51,745
Total Stockholder Equity ($M)$16,236
Profit Ratios
Profit as % of Revenues3.4%
Profits as % of Assets6.6%
Profits as % of Stockholder Equity21.0%
()0.00 0.00 (0)
  • Previous Close:
  • Market Cap: NaNB
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  • 52 Week Change %: 0.00
  • P/E Ratio: n/a
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  • Dividend Yield: n/a

News about Express Scripts Holding

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Cigna Is Buying Express Scripts in a $54 Billion Health Industry Deal

Another move toward consolidation between insurers and the companies that oversee drug benefits.

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Sparking a selloff in the shares of a host of health care-related companies.

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Express Scripts Shares Flop Over 11% on Likely Loss of Its Biggest Customer

Anthem had sued Express Scripts in March last year, accusing it of charging too much for drugs.

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