The briefing will be held by Principal Deputy Press Secretary Sarah Huckabee Sanders rather than Press Secretary Sean Spicer. Sanders delivered her first press briefing last week.
Trump fired Comey on the recommendation of Attorney General Jeff Sessions and Deputy Attorney General Rod Rosenstein.
Spicer will be at the Pentagon for the remainder of the week fulfilling his duty with the Navy Reserve, the White House said, according to CNN.
Watch the press briefing live, scheduled to start at 1:30 p.m. EDT, above.